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Review
. 2005;31(3):261-6.
doi: 10.1385/IR:31:3:261.

Interaction between HSP73 and HLA-DRB1*0401: implications for the development of rheumatoid arthritis

Isabelle Auger  1 , Jean Roudier
Affiliations
Review

Interaction between HSP73 and HLA-DRB1*0401: implications for the development of rheumatoid arthritis

Isabelle Auger et al. Immunol Res. 2005.

Abstract

The amino acid motif QKRAA on HLA-DRB1*0401 carries susceptibility to develop rheumatoid arthritis through unknown mechanisms. We identified the original functions of this motif. In B-cells, HSP73, the constitutive 70-kDa heat-shock protein (HSP), associates with HLA-DRB1*0401. This interaction causes abnormal trafficking of HLA-DRB1*0401. Indeed, HSP73 targets HLA-DRB1*0401 from endoplasmic reticulum to lysosomes bypassing the normal route through the Golgi apparatus and endosomes. In this article, we propose mechanisms to explain how 70-kDa HSPs might contribute to rheumatoid arthritis.

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