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Clinical Trial
. 1992 Mar;58(3):117-20.

[Clebopride in premedication in ambulatory interventions in general anesthesia]

[Article in Italian]
S Migliavacca  1 , R Speranza, M Cipolla, D Laveneziana
Affiliations
  • PMID: 1589071
Clinical Trial

[Clebopride in premedication in ambulatory interventions in general anesthesia]

[Article in Italian]
S Migliavacca et al. Minerva Anestesiol. 1992 Mar.

Abstract

The authors examine the antiemetic effects of 1 mg clebopride administered iv after surgery, vs a placebo, by making a double blind randomized study on two groups of 40 women comparable by age and weight. The 2 groups of outpatients, admitted for short gynecological surgery, underwent diagnostic uterine curettage. They were anaesthetized with a cocktail of 2.5 mcg/kg fentanyl and 0.25 mg/kg ketamine, on spontaneous respiration. Nausea, vomiting and the other side effects were evaluated 3-6 hours after surgery. Statistically, clebopride proved more effective than placebo against nausea and vomiting (P ranging between 0.05-0.01), with no relevant side effects.

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