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. 2005 Jun 17;308(5729):1758-62.
doi: 10.1126/science.1113010. Epub 2005 May 12.

Tubulin polyglutamylase enzymes are members of the TTL domain protein family

Carsten Janke  1 , Krzysztof Rogowski, Dorota Wloga, Catherine Regnard, Andrey V Kajava, Jean-Marc Strub, Nevzat Temurak, Juliette van Dijk, Dominique Boucher, Alain van Dorsselaer, Swati Suryavanshi, Jacek Gaertig, Bernard Eddé
Affiliations

Tubulin polyglutamylase enzymes are members of the TTL domain protein family

Carsten Janke et al. Science. .

Abstract

Polyglutamylation of tubulin has been implicated in several functions of microtubules, but the identification of the responsible enzyme(s) has been challenging. We found that the neuronal tubulin polyglutamylase is a protein complex containing a tubulin tyrosine ligase-like (TTLL) protein, TTLL1. TTLL1 is a member of a large family of proteins with a TTL homology domain, whose members could catalyze ligations of diverse amino acids to tubulins or other substrates. In the model protist Tetrahymena thermophila, two conserved types of polyglutamylases were characterized that differ in substrate preference and subcellular localization.

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