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Review
. 2005 Jun;79(11):6577-87.
doi: 10.1128/JVI.79.11.6577-6587.2005.

Plunder and stowaways: incorporation of cellular proteins by enveloped viruses

Réjean Cantin  1 , Sylvie Méthot, Michel J Tremblay
Affiliations
Review

Plunder and stowaways: incorporation of cellular proteins by enveloped viruses

Réjean Cantin et al. J Virol. 2005 Jun.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Schematicrepresentation of the intimate link between viral components and the human MVB pathway. Cargo proteins to be sorted are first monoubiquitinated and then bound to the Hrs complex in the early endosomes. After fusion of the early endosomes and the sorting endosomes, the cargo proteins are initially transferred to the ESCRT-I complex and then relayed successively to the ESCRT-II and ESCRT-III complexes. Finally, under the action of the VPS4A/B enzyme, cargo proteins are released into an intraluminal vesicle in formation. Monoubiquitinated structural proteins of enveloped viruses mimic cellular cargo proteins and enter the MVB pathway to be released at the site of virus budding. Proteins highlighted in yellow are incorporated within different retroviruses, as described in the text. Ub, ubiquitin; STAM, signal-transducing adapter molecule; EAP, ELL-associated proteins; CHMP, charged multivesicular body protein.
See this image and copyright information in PMC

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