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Review
. 2005 May 13;18(4):393-4.
doi: 10.1016/j.molcel.2005.04.018.

How cholesterol-dependent cytolysins bite holes into membranes

Thomas Walz  1
Affiliations
Review

How cholesterol-dependent cytolysins bite holes into membranes

Thomas Walz. Mol Cell. .

Abstract

In a show piece for electron microscopy (EM), Tilley at al. used single-particle cryo-EM to visualize the structural rearrangements in the bacterial toxin pneumolysin that occur when it assembles into a membrane-associated prepore and when the prepore subsequently transitions into a fully membrane-inserted pore.

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