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Comparative Study
. 2005 Jun 15;15(12):3177-80.
doi: 10.1016/j.bmcl.2005.03.121.

Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents

B A Bhat  1 , K L Dhar, S C Puri, A K Saxena, M Shanmugavel, G N Qazi
Affiliations
Comparative Study

Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents

B A Bhat et al. Bioorg Med Chem Lett. .

Abstract

A series of substituted chalcones and their corresponding pyrazoles were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. Out of 93 compounds screened, 8 compounds, 1s, 3i,j,n, 4i,j,n and 4s, showed marked activity. Compounds 4j,n and 4s were found to be the most promising in this study. SAR is also discussed.

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