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Comparative Study
. 2005 Jun 7;1046(1-2):230-3.
doi: 10.1016/j.brainres.2005.04.019.

Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA

Tetsuya Maeda  1 , Ken Nagata, Yasuji Yoshida, Kazuya Kannari
Affiliations
Comparative Study

Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA

Tetsuya Maeda et al. Brain Res. .

Abstract

The aim of this study was to determine whether raphe-striatal serotonergic neurons of adult rats with extensive nigro-striatal dopaminergic denervation are induced by injection of exogenous L-DOPA to contain dopamine. Double-labeling immunofluorescence study was conducted. In the lesioned striatum of rats that received L-DOPA, serotonergic hyperinnervation was observed, and dopamine was detected in serotonergic varicose fibers. These findings suggest that striatal serotonergic hyperinnervation can compensate for the lost function of dopaminergic neurons.

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