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Comment
. 2005 Jul;145(6):699-700.
doi: 10.1038/sj.bjp.0706261.

Cardioprotection with adenosine: 'a riddle wrapped in a mystery'

Karin Przyklenk  1 , Peter Whittaker
Affiliations
Comment

Cardioprotection with adenosine: 'a riddle wrapped in a mystery'

Karin Przyklenk et al. Br J Pharmacol. 2005 Jul.

Abstract

Review of the published literature on adenosine and cardioprotection could lead one to paraphrase the famous words of Sir Winston Churchill (Radio broadcast, 1 October 1939 (in reference to Russia)) and conclude: 'I cannot forecast to you the action of adenosine. It is a riddle wrapped in a mystery inside an enigma'. That is, although it is well-established that adenosine can render cardiomyocytes resistant to lethal ischemia/reperfusion-induced injury, new and intriguing insights continue to emerge as to the mechanisms by which adenosine might limit myocardial infarct size.

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References

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