doi: 10.1016/j.bbrc.2005.03.075.
Epub 2005 Mar 30.
Is NF-kappaB a culprit in type 2 diabetes?
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- PMID: 15896290
- DOI: 10.1016/j.bbrc.2005.03.075
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Is NF-kappaB a culprit in type 2 diabetes?
Biochem Biophys Res Commun.
.
Abstract
It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. Earlier studies indicated that IKKbeta was the key for the development of insulin resistance. However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles in insulin resistance. New data suggest that NF-kappaB and NF-kappaB-regulated cytokines are crucial for the diabetogenesis.
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