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Review
. 2005 May;30(5):240-4.
doi: 10.1016/j.tibs.2005.03.008.

The yeast Mediator complex and its regulation

Stefan Björklund  1 , Claes M Gustafsson
Affiliations
Review

The yeast Mediator complex and its regulation

Stefan Björklund et al. Trends Biochem Sci. 2005 May.

Abstract

The Mediator complex acts as a bridge, conveying regulatory information from enhancers and other control elements to the basal RNA polymerase II transcription machinery. Mediator is required for the regulated transcription of nearly all RNA polymerase II-dependent genes in Saccharomyces cerevisiae, and post-translational modifications of specific Mediator subunits can affect global patterns of gene transcription.

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