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Review
. 2005 May;30(5):250-5.
doi: 10.1016/j.tibs.2005.03.002.

The mammalian Mediator complex and its role in transcriptional regulation

Ronald C Conaway  1 , Shigeo Sato, Chieri Tomomori-Sato, Tingting Yao, Joan W Conaway
Affiliations
Review

The mammalian Mediator complex and its role in transcriptional regulation

Ronald C Conaway et al. Trends Biochem Sci. 2005 May.

Abstract

Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.

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