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. 2005 Aug 1;13(15):4645-50.
doi: 10.1016/j.bmc.2005.04.061.

Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents

Anu Agarwal  1 , Kumkum Srivastava, S K Puri, Prem M S Chauhan
Affiliations

Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents

Anu Agarwal et al. Bioorg Med Chem. .

Abstract

A series of 2,4,6-trisubstituted-pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds have shown MIC in the range of 0.25-2 microg/mL. These compounds are in vitro severalfold more active than pyrimethamine.

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