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Review
. 2005 Apr;2(2):384-93.
doi: 10.1602/neurorx.2.2.384.

Neuroimaging of epilepsy: therapeutic implications

Ruben I Kuzniecky  1
Affiliations
Review

Neuroimaging of epilepsy: therapeutic implications

Ruben I Kuzniecky. NeuroRx. 2005 Apr.

Abstract

Neuroimaging has important applications in the diagnosis and treatment of patients with seizures and epilepsy. Having replaced computed tomography (CT) in many situations, MRI is the preferred imaging technique for patients with epilepsy. Advances in radionuclide-based techniques such as single-photon emission CT/positron emission tomography and electromagnetic source imaging with magnetoencephalography are providing new insights into the pathophysiology of epilepsy. In addition, techniques such as magnetic resonance spectroscopy are beginning to impact treatment. In this review, I discuss how these techniques are used in clinical practice but more importantly, how imaging findings play an increasing role in neurotherapeutics.

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Figures

FIG. 1.
FIG. 1.
Hippocampal Sclerosis. T2-W coronal MRI shows evidence of right hippocampal sclerosis. Note signal changes and atrophy from right hippocampus. Surgical outcome: seizure free for 3 years.
FIG. 2.
FIG. 2.
Periventricular band heterotopia due to Filamin 1 (FLM) mutation. Note periventricular gray matter nodules.
FIG. 3.
FIG. 3.
MRI of a patient with lisencephaly due to DCX mutation. Note thick gray matter smooth cortex. Genetic counseling and testing indicated in family.
See this image and copyright information in PMC

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