Review
Muraglitazar (Bristol-Myers Squibb/Merck)
Affiliations
- PMID: 15898350
Item in Clipboard
Review
Muraglitazar (Bristol-Myers Squibb/Merck)
Curr Opin Investig Drugs.
2005 Apr.
Free article
Abstract
Bristol-Myers Squibb and Merck & Co are co-developing muraglitazar, a dual peroxisome proliferator-activated receptor-alpha/gamma agonist, for the potential treatment of type 2 diabetes and other metabolic disorders. In November 2004, approval was anticipated as early as mid-2005.
Similar articles
-
Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.J Med Chem. 2005 Mar 24;48(6):2248-50. doi: 10.1021/jm0496436. J Med Chem. 2005. PMID: 15771468
-
Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.Diabetes. 2006 Jan;55(1):240-8. Diabetes. 2006. PMID: 16380499
-
Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study.Diabetes Care. 2006 May;29(5):1016-23. doi: 10.2337/diacare.2951016. Diabetes Care. 2006. PMID: 16644631 Clinical Trial.
-
PPARalpha and PPARgamma dual agonists for the treatment of type 2 diabetes and the metabolic syndrome.Curr Opin Pharmacol. 2006 Dec;6(6):606-14. doi: 10.1016/j.coph.2006.06.009. Epub 2006 Sep 14. Curr Opin Pharmacol. 2006. PMID: 16973418 Review.
-
BMS-193884 and BMS-207940 Bristol-Myers Squibb.Curr Opin Investig Drugs. 2002 Jul;3(7):1057-61. Curr Opin Investig Drugs. 2002. PMID: 12186267 Review.
Cited by
-
Drugs on the horizon for diabesity.Curr Diab Rep. 2005 Oct;5(5):353-9. doi: 10.1007/s11892-005-0093-1. Curr Diab Rep. 2005. PMID: 16188170 Review.
-
Increase in weight induced by muraglitazar, a dual PPARalpha/gamma agonist, in db/db mice: adipogenesis/or oedema?Br J Pharmacol. 2007 Feb;150(4):480-7. doi: 10.1038/sj.bjp.0707000. Epub 2007 Jan 8. Br J Pharmacol. 2007. PMID: 17211457 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
