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. 2005 May 28:(20):2558-60.
doi: 10.1039/b500686d. Epub 2005 Mar 22.

Biosynthesis of conjugatable saccharidic moieties of GM2 and GM3 gangliosides by engineered E. coli

Sébastien Fort  1 , Lemonia Birikaki, Marie-Pierre Dubois, Tatiana Antoine, Eric Samain, Hugues Driguez
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Biosynthesis of conjugatable saccharidic moieties of GM2 and GM3 gangliosides by engineered E. coli

Sébastien Fort et al. Chem Commun (Camb). .

Abstract

Oligosaccharidic moieties of GM(2) and GM(3) gangliosides bearing an allyl or a propargyl aglycon, are efficiently biosynthesized on the gram scale by growing metabolically engineered Escherichia coli cells in the presence of the corresponding lactoside acceptors and sialic acid.

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