Ro's role in RNA reconnaissance

Ian J MacRae¹, Jennifer A Doudna²

Affiliations

¹ Howard Hughes Medical Institute, Department of Molecular & Cell Biology and Department of Chemistry, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720; Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720.
² Howard Hughes Medical Institute, Department of Molecular & Cell Biology and Department of Chemistry, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720; Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720. Electronic address: doudna@uclink.berkeley.edu.

PMID: 15907458
DOI: 10.1016/j.cell.2005.05.004

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Review

Ro's role in RNA reconnaissance

Ian J MacRae et al. Cell. 2005.

Free article

. 2005 May 20;121(4):495-496.

doi: 10.1016/j.cell.2005.05.004.

Authors

Ian J MacRae¹, Jennifer A Doudna²

Affiliations

¹ Howard Hughes Medical Institute, Department of Molecular & Cell Biology and Department of Chemistry, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720; Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720.
² Howard Hughes Medical Institute, Department of Molecular & Cell Biology and Department of Chemistry, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720; Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720. Electronic address: doudna@uclink.berkeley.edu.

PMID: 15907458
DOI: 10.1016/j.cell.2005.05.004

Abstract

The Ro 60 kDa autoantigen binds misfolded RNAs and likely functions in small RNA quality control. In this issue of Cell, Stein et al. (2005) present crystal structures of Ro alone and bound to both double- and single-stranded RNA, revealing two distinct RNA binding sites that suggest how Ro may distinguish between native and misfolded small RNAs.

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Comment on

Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity.
Stein AJ, Fuchs G, Fu C, Wolin SL, Reinisch KM. Stein AJ, et al. Cell. 2005 May 20;121(4):529-539. doi: 10.1016/j.cell.2005.03.009. Cell. 2005. PMID: 15907467 Free PMC article.

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- NCI CPTC Antibody Characterization Program

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Ro's role in RNA reconnaissance

Affiliations

Ro's role in RNA reconnaissance

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Abstract

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Research Materials