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Comment
. 2005 May 20;121(4):496-497.
doi: 10.1016/j.cell.2005.05.002.

A new view of an old pore

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A new view of an old pore

Sandra Bajjalieh. Cell. .
Free article

Abstract

Despite reports suggesting a potential role in membrane fusion, the V(0) subunit of the (+)H/ATPase has remained an unlikely candidate for the fusion pore. In this issue of Cell, Hiesinger and coworkers (Hiesinger et al., 2005) present a forward genetic screen that reveals it to be necessary for synaptic vesicle fusion, independent of its role in vesicle acidification.

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