A new view of an old pore
- PMID: 15907459
- DOI: 10.1016/j.cell.2005.05.002
A new view of an old pore
Abstract
Despite reports suggesting a potential role in membrane fusion, the V(0) subunit of the (+)H/ATPase has remained an unlikely candidate for the fusion pore. In this issue of Cell, Hiesinger and coworkers (Hiesinger et al., 2005) present a forward genetic screen that reveals it to be necessary for synaptic vesicle fusion, independent of its role in vesicle acidification.
Comment on
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The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.Cell. 2005 May 20;121(4):607-620. doi: 10.1016/j.cell.2005.03.012. Cell. 2005. PMID: 15907473 Free PMC article.
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