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Review
. 2005 May 20;121(4):499-501.
doi: 10.1016/j.cell.2005.05.003.

No rest for REST: REST/NRSF regulation of neurogenesis

Victoria V Lunyak  1 , Michael G Rosenfeld  2
Affiliations
Free article
Review

No rest for REST: REST/NRSF regulation of neurogenesis

Victoria V Lunyak et al. Cell. .
Free article

Abstract

Epigenetic strategies control the orderly acquisition and maintenance of neuronal traits. A complex network of transcriptional repressors and co-repressors mediates gene specificity for these strategies. In this issue of Cell, a study by Ballas and coworkers (Ballas et al., 2005) provides insight into the early lineage commitment events during neurogenesis. This study demonstrates that regulation of the REST/NRSF transcriptional repressor plays a fundamental role in the progression of pluripotent cells to lineage-restricted neural progenitors.

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