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. 1992 May 1;283 ( Pt 3)(Pt 3):661-4.
doi: 10.1042/bj2830661.

Antizyme, a protein induced by polyamines, accelerates the degradation of ornithine decarboxylase in Chinese-hamster ovary-cell extracts

Y Murakami  1 , K Tanaka, S Matsufuji, Y Miyazaki, S Hayashi
Affiliations

Antizyme, a protein induced by polyamines, accelerates the degradation of ornithine decarboxylase in Chinese-hamster ovary-cell extracts

Y Murakami et al. Biochem J. .

Abstract

Ornithine decarboxylase (ODC), the key regulatory enzyme for polyamine biosynthesis, is known to have a short intracellular half-life, and antizyme, an ODC-binding protein induced by polyamines, has been suggested to be involved in the process of ODC degradation. In the present study we demonstrated that antizyme markedly accelerated ATP-dependent degradation of ODC in vitro in an extract from ODC-overproducing Chinese-hamster ovary cells.

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