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. 2005 Jun 15;15(12):3024-8.
doi: 10.1016/j.bmcl.2005.04.033.

Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites

Franck Chouteau  1 , David Ramanitrahasimbola, Philippe Rasoanaivo, Kelly Chibale
Affiliations

Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites

Franck Chouteau et al. Bioorg Med Chem Lett. .

Abstract

An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasmodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria. ortho-Substituted bromo and biphenyl ether compounds displayed the best activity from the series.

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