Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Jun;32(3):315-21.
doi: 10.1016/j.transci.2005.03.003.

Chronic red blood cell exchange to prevent clinical complications in sickle cell disease

Sergio Cabibbo  1 , Carmelo Fidone, Giovanni Garozzo, Agostino Antolino, Giovanna Oriella Manenti, Francesco Bennardello, Vincenzo Licitra, Salvatore Calabrese, Francesco Costantino, Simone Travali, Roberto Distefano, Pietro Bonomo
Affiliations

Chronic red blood cell exchange to prevent clinical complications in sickle cell disease

Sergio Cabibbo et al. Transfus Apher Sci. 2005 Jun.

Abstract

We tracked the results of 394 manual or automatic red blood cell exchanges done with a cell separator in 20 sickle cell patients at high risk for recurrent complications. Over an average of 6 years, none of the patients developed complications related to the procedure or to the increased blood use. It was safe and effective in preventing complications of sickle cell disease, and if done automatically, reduced iron overload. Ferritin levels also decreased in patients treated with automatic red blood cell exchange. Furthermore, using Single Donor Red Blood Cell units (SDRC) we reduced the potential exposure to transfusion transmitted infectious diseases (TTI).

PubMed Disclaimer

LinkOut - more resources