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. 2005 Jun;73(6):3814-6.
doi: 10.1128/IAI.73.6.3814-3816.2005.

Boosting with poxviruses enhances Mycobacterium bovis BCG efficacy against tuberculosis in guinea pigs

A Williams  1 , N P Goonetilleke, H McShane, Simon O Clark, Graham Hatch, S C Gilbert, A V S Hill
Affiliations

Boosting with poxviruses enhances Mycobacterium bovis BCG efficacy against tuberculosis in guinea pigs

A Williams et al. Infect Immun. 2005 Jun.

Abstract

Tuberculosis is rising in the developing world due to poor health care, human immunodeficiency virus type 1 infection, and the low protective efficacy of the Mycobacterium bovis BCG vaccine. A new vaccination strategy that could protect adults in the developing world from tuberculosis could have a huge impact on public health. We show that BCG boosted by poxviruses expressing antigen 85A induced unprecedented 100% protection of guinea pigs from high-dose aerosol challenge with Mycobacterium tuberculosis, suggesting a strategy for enhancing and prolonging the efficacy of BCG.

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Figures

FIG. 1.
FIG. 1.
Kaplan-Meier curves of the survival of guinea pigs post-aerosol challenge with M. tuberculosis. Six animals per group were vaccinated with BCG, BCG-MVA85A-FP9.Ag85A, or saline.
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