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Case Reports
. 2005 Jun 15;40(12):e113-6.
doi: 10.1086/430441. Epub 2005 May 3.

Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?

Lluis Palenzuela  1 , Noah M Hahn, Robert P Nelson Jr, Janet N Arno, Carol Schobert, Robert Bethel, Lisa A Ostrowski, Manjuli R Sharma, Partha P Datta, Rajendra K Agrawal, Jennifer E Schwartz, Michio Hirano
Affiliations
Case Reports

Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?

Lluis Palenzuela et al. Clin Infect Dis. .

Abstract

Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.

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