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. 2005 Apr;35(2):159-66.
doi: 10.1007/s10803-004-1993-7.

Asperger syndrome: familial and pre- and perinatal factors

Christopher Gillberg  1 , Mats Cederlund
Affiliations

Asperger syndrome: familial and pre- and perinatal factors

Christopher Gillberg et al. J Autism Dev Disord. 2005 Apr.

Abstract

Objective: Study familial and pre- and perinatal factors in Asperger Syndrome (AS).

Methods: One hundred boys with AS had their records reviewed. "Pathogenetic subgroups" were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage.

Results: No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55%.

Comment: About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.

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