doi: 10.1016/j.farmac.2005.03.003.
Epub 2005 Apr 25.
Complexation of fluoxetine hydrochloride with beta-cyclodextrin. A proton magnetic resonance study in aqueous solution
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- PMID: 15910817
- DOI: 10.1016/j.farmac.2005.03.003
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Complexation of fluoxetine hydrochloride with beta-cyclodextrin. A proton magnetic resonance study in aqueous solution
Farmaco.
2005 May.
Abstract
A proton magnetic resonance spectroscopic study in D2O of mixtures of fluoxetine hydrochloride (guest) with beta-cyclodextrin (host) revealed the existence of two different equilibria for 1:1 inclusion complexes in which -CF3 substituted ring of the guest is more tightly held by the host cavity. The structures of the two complexes have been proposed which are supported by 2DROESY spectral data. The dissociation constant was also determined.
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