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Comment
. 2005 May 31;102(22):7781-2.
doi: 10.1073/pnas.0503261102. Epub 2005 May 23.

Molecular engineering human hepatocytes into pancreatic beta cells for diabetes therapy

Irene Cozar-Castellano  1 , Andrew F Stewart
Affiliations
Comment

Molecular engineering human hepatocytes into pancreatic beta cells for diabetes therapy

Irene Cozar-Castellano et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
The hepatocyte-to-beta cell transdifferentiation paradigm. Hepatocytes are obtained by liver biopsy from a donor or patient with diabetes, cultured and expanded ex vivo, transduced with a pdx-1 virus, transdifferentiated into functioning, insulin-producing beta cells, and then transplanted into a patient with diabetes.
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