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Comment
. 2005 May 31;102(22):7779-80.
doi: 10.1073/pnas.0503088102. Epub 2005 May 23.

Autophagy and intracellular surveillance: Modulating MHC class II antigen presentation with stress

Victoria L Crotzer  1 , Janice S Blum
Affiliations
Comment

Autophagy and intracellular surveillance: Modulating MHC class II antigen presentation with stress

Victoria L Crotzer et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Multiple pathways of protein degradation in lysosomes. In microautophagy, portions of the cytosol are continuously internalized via lysosomal invaginations. In macroautophagy, the cytoplasm is sequestered into double-membraned structures, known as autophagosomes, which fuse with lysosomes. In CMA, specific cytosolic proteins are transported into lysosomes via a molecular chaperone/receptor complex composed of hsc70 and lamp-2. Cytoplasmic antigens may first be processed by cytosolic proteases before transport to lysosomes. These antigenic fragments intersect with MHC class II molecules in a mature endosomal compartment known as the MIIC before presentation to CD4+ T cells.
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