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. 2005 Oct 15;101(1):112-4.
doi: 10.1016/j.imlet.2005.04.008.

The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: genetic variability and subtypes

Xiao-Nan Dong  1 , Yi Wu, Jian Ying, Ying-Hua Chen
Affiliations

The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: genetic variability and subtypes

Xiao-Nan Dong et al. Immunol Lett. .

Abstract

V3 loop on HIV-1 gp120 is tightly correlated with syncytium formation, coreceptor usage, virus infectivity and antibody neutralization. The antigenic tip GPGRAFY with its flanking sequence has a conserved secondary structure, and is the target of neutralizing antibodies. We analyzed its genetic variability in 30096 M-group isolates and 269 O-group isolates. Subtype-related restricted mutations were observed, which could help to identify subtypes.

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