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Review
. 2005 May;81(4):294-300.
doi: 10.1532/IJH97.05011.

Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes

Atsushi Iwama  1 , Hideyuki Oguro, Masamitsu Negishi, Yuko Kato, Hiromitsu Nakauchi
Affiliations
Review

Epigenetic regulation of hematopoietic stem cell self-renewal by polycomb group genes

Atsushi Iwama et al. Int J Hematol. 2005 May.

Abstract

Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi-1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.

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References

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