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Comparative Study
. 1992 Jan-Mar;8(1):63-73.
doi: 10.1007/BF00119295.

The effect of K+/H+ antiporter nigericin on gap junction permeability

I V Budunova  1 , L A Mittelman
Affiliations
Comparative Study

The effect of K+/H+ antiporter nigericin on gap junction permeability

I V Budunova et al. Cell Biol Toxicol. 1992 Jan-Mar.

Abstract

The K+/H+ antiporter nigericin inhibits the intercellular exchange of the fluorescent dye Lucifer Yellow between DM15-transformed fibroblasts derived from the Djungarian hamster. The efficacy of nigericin action was related to its concentration and time of incubation. The nigericin-induced uncoupling effect on gap junctions was reversible and was shown to be based on its ability to cause cystolic acidification. The effect of nigericin on dye-coupling in intact and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-pretreated cells did not differ, indicating that the uncoupling effect of H+ on gap junctions in DM15 cells was not mediated by the TPA-dependent isoform of protein kinase C.

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