Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 Jan-Mar;8(1):63-73.
doi: 10.1007/BF00119295.

The effect of K+/H+ antiporter nigericin on gap junction permeability

I V Budunova  1 , L A Mittelman
Affiliations
Comparative Study

The effect of K+/H+ antiporter nigericin on gap junction permeability

I V Budunova et al. Cell Biol Toxicol. 1992 Jan-Mar.

Abstract

The K+/H+ antiporter nigericin inhibits the intercellular exchange of the fluorescent dye Lucifer Yellow between DM15-transformed fibroblasts derived from the Djungarian hamster. The efficacy of nigericin action was related to its concentration and time of incubation. The nigericin-induced uncoupling effect on gap junctions was reversible and was shown to be based on its ability to cause cystolic acidification. The effect of nigericin on dye-coupling in intact and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-pretreated cells did not differ, indicating that the uncoupling effect of H+ on gap junctions in DM15 cells was not mediated by the TPA-dependent isoform of protein kinase C.

PubMed Disclaimer

References

    1. Cell Biol Toxicol. 1989 Jan;5(1):77-89 - PubMed
    1. J Membr Biol. 1986;90(1):1-12 - PubMed
    1. Experientia. 1987 Oct 15;43(10):1084-91 - PubMed
    1. J Biol Chem. 1986 Oct 5;261(28):13013-8 - PubMed
    1. Br J Cancer Suppl. 1988 Dec;9:52-7 - PubMed

Publication types

LinkOut - more resources