Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2005 Jun;49(6):2504-6.
doi: 10.1128/AAC.49.6.2504-2506.2005.

Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid

Edmund V Capparelli  1 , Scott L Letendre, Ronald J Ellis, Parul Patel, Diane Holland, J Allen McCutchan
Affiliations
Clinical Trial

Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid

Edmund V Capparelli et al. Antimicrob Agents Chemother. 2005 Jun.

Abstract

The distribution of abacavir into the cerebrospinal fluid (CSF) was assessed by use of a population pharmacokinetic analysis. Plasma and CSF abacavir concentrations in 54 subjects were determined. The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Abacavir CSF and plasma concentrations.
See this image and copyright information in PMC

References

    1. Beal, S. L., and L. B. Sheiner (ed.). 1992. NONMEM user guides. NONMEM Project Group, University of California, San Francisco.
    1. Cherubin, C. E., R. H. Eng, R. Norrby, J. Modai, G. Humbert, and G. Overturf. 1989. Penetration of newer cephalosporins into cerebrospinal fluid. Rev. Infect. Dis. 11:526-548. - PubMed
    1. Daluge, S. M., S. S. Good, M. B. Faletto, W. H. Miller, M. H. St. Clair, L. R. Boone, M. Tisdale, N. R. Parry, J. E. Reardon, R. E. Dornsife, D. R. Averett, and T. A. Krenitsky. 1997. 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob. Agents Chemother. 41:1082-1093. - PMC - PubMed
    1. Ellis, R. J., A. C. Gamst, E. Capparelli, S. A. Spector, K. Hsia, T. Wolfson, I. Abramson, I. Grant, and J. A. McCutchan. 2000. Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources. Neurology 54:927-936. - PubMed
    1. Foudraine, N. A., R. M. Hoetelmans, J. M. Lange, F. de Wolf, B. H. van Benthem, J. J. Maas, I. P. Keet, and P. Portegies. 1998. Cerebrospinal-fluid HIV-1 RNA and drug concentrations after treatment with lamivudine plus zidovudine or stavudine. Lancet 351:1547-1551. - PubMed

Publication types

MeSH terms