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. 2005 Jun;49(6):2507-9.
doi: 10.1128/AAC.49.6.2507-2509.2005.

In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections

Andrea Giacometti  1 , Oscar Cirioni, Wojciech Kamysz, Carmela Silvestri, Maria Simona Del Prete, Alberto Licci, Giuseppina D'Amato, Jerzy Łukasiak, Giorgio Scalise
Affiliations

In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections

Andrea Giacometti et al. Antimicrob Agents Chemother. 2005 Jun.

Abstract

The in vitro activity of citropin 1.1 against gram-positive cocci was measured by MIC, minimal bactericidal concentration, time-kill studies, and a checkerboard titration method. Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline.

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Figures

FIG. 1.
FIG. 1.
Time-kill kinetics of citropin 1.1 against the quality control strains methicillin-susceptible (MR) S. aureus ATCC 29213, methicillin-resistant (MR) S. aureus ATCC 43300, vancomycin-susceptible (VS) E. faecalis ATCC 29212, vancomycin-resistant (VR) E. faecalis ATCC 51299, and S. pyogenes ATCC 19615.
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