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Case Reports
. 2005 Jul;47(7):520-4.
doi: 10.1007/s00234-005-1368-6. Epub 2005 May 26.

Diffusion-weighted magnetic resonance imaging in Marchiafava-Bignami disease: follow-up studies

C Hlaihel  1 , P-M Gonnaud, S Champin, H Rousset, V-A Tran-Minh, F Cotton
Affiliations
Case Reports

Diffusion-weighted magnetic resonance imaging in Marchiafava-Bignami disease: follow-up studies

C Hlaihel et al. Neuroradiology. 2005 Jul.

Abstract

Marchiafava-Bignami disease (MBD), an acute toxic demyelination of the corpus callosum in alcoholics, is associated with poor evolution in the majority of patients. We report here the early and late diffusion magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) studies of two patients suffering from MBD with favourable outcome. Diffusion and anatomical MRI changes were parallel to the clinical evolution, suggesting that MRI studies can be helpful for diagnosis and follow-up. Unlike in stroke, restricted diffusion on ADC maps does not seem to be a sign of irreversibility.

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