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Review
. 2005 Mar-Apr;140(3-4):265-86.
doi: 10.1016/j.cca.2005.04.004.

Marine pharmacology in 2001--2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action

Alejandro M S Mayer  1 , Mark T Hamann
Affiliations
Review

Marine pharmacology in 2001--2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action

Alejandro M S Mayer et al. Comp Biochem Physiol C Toxicol Pharmacol. 2005 Mar-Apr.

Abstract

During 2001--2002, research on the pharmacology of marine chemicals continued to be global in nature involving investigators from Argentina, Australia, Brazil, Canada, China, Denmark, France, Germany, India, Indonesia, Israel, Italy, Japan, Mexico, Netherlands, New Zealand, Pakistan, the Philippines, Russia, Singapore, Slovenia, South Africa, South Korea, Spain, Sweden, Switzerland, Thailand, United Kingdom, and the United States. This current article, a sequel to the authors' 1998, 1999 and 2000 marine pharmacology reviews, classifies 106 marine chemicals derived from a diverse group of marine animals, algae, fungi and bacteria, on the basis of peer-reviewed preclinical pharmacology. Anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antiprotozoal, antituberculosis or antiviral activities were reported for 56 marine chemicals. An additional 19 marine compounds were shown to have significant effects on the cardiovascular, immune and nervous system as well as to possess anti-inflammatory and antidiabetic effects. Finally, 31 marine compounds were reported to act on a variety of molecular targets and thus may potentially contribute to several pharmacological classes. Thus, during 2001--2002 pharmacological research with marine chemicals continued to contribute potentially novel chemical leads for the ongoing global search for therapeutic agents for the treatment of multiple disease categories.

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Figures

Fig. 1
Fig. 1
Marine pharmacology in 2001–2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities.
Fig. 1
Fig. 1
Marine pharmacology in 2001–2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities.
Fig. 1
Fig. 1
Marine pharmacology in 2001–2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities.
Fig. 1
Fig. 1
Marine pharmacology in 2001–2002: marine compounds with anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities.
Fig. 2
Fig. 2
Marine pharmacology in 2001–2002: marine compounds with anti-inflammatory and antidiabetic activities and affecting the cardiovascular, immune and nervous systems.
Fig. 2
Fig. 2
Marine pharmacology in 2001–2002: marine compounds with anti-inflammatory and antidiabetic activities and affecting the cardiovascular, immune and nervous systems.
Fig. 3
Fig. 3
Marine pharmacology in 2001–2002: marine compounds with miscellaneous mechanisms of action.
Fig. 3
Fig. 3
Marine pharmacology in 2001–2002: marine compounds with miscellaneous mechanisms of action.
Fig. 3
Fig. 3
Marine pharmacology in 2001–2002: marine compounds with miscellaneous mechanisms of action.
See this image and copyright information in PMC

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