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. 2005 May;68(5):678-80.
doi: 10.1021/np049688+.

Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus

Yin Tian  1 , Hongzhu Guo, Jian Han, Dean Guo
Affiliations

Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus

Yin Tian et al. J Nat Prod. 2005 May.

Abstract

Microbial biotransformation of 20(S)-protopanaxatriol (1) by the fungus Mucor spinosus (AS 3.3450) yielded four new metabolites, the structures of which were determined to be 12-oxo-15alpha-hydroxyl-20(S)-protopanaxatriol (2), 27-hydroxyl-20(S)-protopanaxatriol (3), 12-oxo-26-hydroxyl-20(S)-protopanaxatriol (4), and 12-oxo-27-hydroxyl-20(S)-protopanaxatriol (5), respectively, on the basis of their chemical and spectroscopic data. All the new metabolites, as well as the substrate, had significant cytotoxic effects on HL-60 cells (human leukemia cells).

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