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. 2005 May;68(5):734-8.
doi: 10.1021/np050028u.

Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora

Sophie Susplugas  1 , Nguyen Van Hung, Jérôme Bignon, Odile Thoison, Anna Kruczynski, Thierry Sévenet, Françoise Guéritte
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Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora

Sophie Susplugas et al. J Nat Prod. 2005 May.

Abstract

One new norlignan (1) and five new lignans (2-6) were isolated from the leaves and stems of Justicia patentiflora by a bioassay-guided purification. Five known compounds, carinatone, diphyllin, justicidin A, taiwanin E, and tuberculatin, were also found in J. patentiflora. Most of the new compounds display significant activity in in vitro cytotoxic assays against KB, HCT116, and MCF-7 cancer cell lines and arrest the cell cycle in the G0/G1 phase.

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