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. 2005 May 29:6:79.
doi: 10.1186/1471-2164-6-79.

Bcipep: a database of B-cell epitopes

Sudipto Saha  1 , Manoj Bhasin, Gajendra P S Raghava
Affiliations

Bcipep: a database of B-cell epitopes

Sudipto Saha et al. BMC Genomics. .

Abstract

Background: Bcipep is a database of experimentally determined linear B-cell epitopes of varying immunogenicity collected from literature and other publicly available databases.

Results: The current version of Bcipep database contains 3031 entries that include 763 immunodominant, 1797 immunogenic and 471 null-immunogenic epitopes. It covers a wide range of pathogenic organisms like viruses, bacteria, protozoa, and fungi. The database provides a set of tools for the analysis and extraction of data that includes keyword search, peptide mapping and BLAST search. It also provides hyperlinks to various databases such as GenBank, PDB, SWISS-PROT and MHCBN.

Conclusion: A comprehensive database of B-cell epitopes called Bcipep has been developed that covers information on epitopes from a wide range of pathogens. The Bcipep will be source of information for investigators involved in peptide-based vaccine design, disease diagnosis and research in allergy. It should also be a promising data source for the development and evaluation of methods for prediction of B-cell epitopes. The database is available at http://www.imtech.res.in/raghava/bcipep.

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Figures

Figure 1
Figure 1
A schematic representation of Bcipep database.
Figure 2
Figure 2
The typical display of Bcipep database for keyword search; a) input page of keyword search; and b) output of keyword search.
Figure 3
Figure 3
This example illustrate peptide search on Bcipep; a) Peptide search page; and b) result of peptide search.
Figure 4
Figure 4
Mapping of peptide in MHCBN database; a) mapping of MHCBN peptides on B-cell epitope, and b) full information about a MHCBN peptide.
Figure 5
Figure 5
Mapping of B-cell epitopes on antigen sequence, a) submission page of B-cell epitope mapping, and b) mapping results
See this image and copyright information in PMC

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