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Randomized Controlled Trial
. 2005 Jul;90(1):39-43.
doi: 10.1016/j.ijgo.2005.04.004.

Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome

Y M Hwu  1 , S Y Lin, W Y Huang, M H Lin, R K K Lee
Affiliations
Randomized Controlled Trial

Ultra-short metformin pretreatment for clomiphene citrate-resistant polycystic ovary syndrome

Y M Hwu et al. Int J Gynaecol Obstet. 2005 Jul.

Abstract

Objective: To evaluate the effect of ultra-short (12 days) metformin pretreatment in clomiphene-citrate (CC) resistant polycystic ovary syndrome (PCOS).

Method: Eighty women with CC-resistant PCOS were randomly allocated to metformin pretreatment or usual treatment. Forty women received 1500 mg metformin daily for 12 days, followed by clomiphene 150 mg daily for 5 days along with metformin. Forty women (control group) received the same dose of clomiphene but no metformin pretreatment.

Results: In the metformin group, 17 (42.5%) women ovulated, and 6 (15%) conceived. In the control group, 5 (12.5%) women ovulated but none conceived. Compared with the control group, the metformin group had significantly higher ovulation (P = 0.03) and pregnancy rates (P = 0.026).

Conclusion: Twelve days of metformin pretreatment improves ovulation and pregnancy rates in women with CC-resistant PCOS.

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