Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Jun 15;45(8):1013-20.
doi: 10.1016/j.toxicon.2005.02.028. Epub 2005 Apr 19.

Natural inhibitors of snake venom hemorrhagic metalloproteinases

Affiliations
Review

Natural inhibitors of snake venom hemorrhagic metalloproteinases

Jonas Perales et al. Toxicon. .

Abstract

Metalloproteinases play an important role in the poisoning process by snake venoms. They evoke systemic injury, by degrading or activating host blood factors, and local damage by acting on endothelial cell surface proteins. Plasma and/or muscle of venomous and non-venomous snakes as well as of some special mammals possess metalloproteinase inhibitors that behave as soluble acceptors available for a rapid inhibition of the deleterious action of these enzymes. The purpose of this review is to describe the state of the art on natural immunity against snake venom metalloproteinases and to overview this field by discussing the available structural and biological properties of the inhibitors protein/gene families.

PubMed Disclaimer

Publication types