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Comparative Study
. 2005 Jul;164(1-2):124-8.
doi: 10.1016/j.jneuroim.2005.03.011.

Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma

C Luther  1 , S Poeschel, M Varga, A Melms, E Tolosa
Affiliations
Comparative Study

Decreased frequency of intrathymic regulatory T cells in patients with myasthenia-associated thymoma

C Luther et al. J Neuroimmunol. 2005 Jul.

Abstract

Naturally occurring CD4+CD25+ regulatory T cells (Treg) are essential for the control of unwanted autoimmune responses. In this study, we analysed their frequency in peripheral blood and in the thymus/thymomas of patients with myasthenia gravis (MG). We found a marked decrease in the number of CD4+CD25+ thymocytes in MG-associated thymomas, but no differences in the peripheral compartment, suggesting that the thymic development of Treg might be impaired in these patients.

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