Review
doi: 10.1016/j.cbpa.2005.05.002.
Fragonomics: fragment-based drug discovery
Affiliations
- PMID: 15925537
- DOI: 10.1016/j.cbpa.2005.05.002
Item in Clipboard
Review
Fragonomics: fragment-based drug discovery
Curr Opin Chem Biol.
2005 Aug.
Abstract
The use of smaller molecules (fragments) in the drug discovery process has led to success in delivering novel leads for many different targets. This process is a highly integrated process, starting from library design to screening and medicinal chemistry. An overview of this process is presented with particular emphasis placed on the NMR aspect of screening.
Similar articles
-
Fragment-based activity space: smaller is better.Curr Opin Chem Biol. 2008 Jun;12(3):260-8. doi: 10.1016/j.cbpa.2008.02.005. Epub 2008 Mar 19. Curr Opin Chem Biol. 2008. PMID: 18316043 Review.
-
Crystallography, NMR and virtual screening: integrated tools for drug discovery.Curr Opin Drug Discov Devel. 2003 Jul;6(4):544-9. Curr Opin Drug Discov Devel. 2003. PMID: 12951817 Review.
-
Fragment-based screening using X-ray crystallography and NMR spectroscopy.Curr Opin Chem Biol. 2007 Oct;11(5):485-93. doi: 10.1016/j.cbpa.2007.07.010. Epub 2007 Sep 11. Curr Opin Chem Biol. 2007. PMID: 17851109 Review.
-
Fragment-based lead discovery: a chemical update.Curr Opin Biotechnol. 2006 Dec;17(6):643-52. doi: 10.1016/j.copbio.2006.10.007. Epub 2006 Nov 3. Curr Opin Biotechnol. 2006. PMID: 17084612 Review.
-
Using NMR for ligand discovery and optimization.Curr Opin Chem Biol. 2004 Aug;8(4):387-91. doi: 10.1016/j.cbpa.2004.05.002. Curr Opin Chem Biol. 2004. PMID: 15288248 Review.
Cited by
-
High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists.Curr Top Med Chem. 2015;15(20):2032-42. doi: 10.2174/1568026615666150519102459. Curr Top Med Chem. 2015. PMID: 25986689 Free PMC article. Review.
-
NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.Chem Rev. 2014 May 14;114(9):4749-63. doi: 10.1021/cr500043b. Epub 2014 Apr 8. Chem Rev. 2014. PMID: 24712885 Free PMC article. Review. No abstract available.
-
Targeting zinc finger domains with small molecules: solution structure and binding studies of the RanBP2-type zinc finger of RBM5.Chembiochem. 2011 Dec 16;12(18):2837-45. doi: 10.1002/cbic.201100582. Chembiochem. 2011. PMID: 22162216 Free PMC article.
-
Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.Curr Top Med Chem. 2009;9(18):1678-87. doi: 10.2174/156802609790102383. Curr Top Med Chem. 2009. PMID: 19929835 Free PMC article. Review.
-
Perspectives on NMR in drug discovery: a technique comes of age.Nat Rev Drug Discov. 2008 Sep;7(9):738-45. doi: 10.1038/nrd2606. Nat Rev Drug Discov. 2008. PMID: 19172689 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
