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Review
. 2005 Aug;9(4):366-70.
doi: 10.1016/j.cbpa.2005.05.002.

Fragonomics: fragment-based drug discovery

Edward R Zartler  1 , Michael J Shapiro
Affiliations
Review

Fragonomics: fragment-based drug discovery

Edward R Zartler et al. Curr Opin Chem Biol. 2005 Aug.

Abstract

The use of smaller molecules (fragments) in the drug discovery process has led to success in delivering novel leads for many different targets. This process is a highly integrated process, starting from library design to screening and medicinal chemistry. An overview of this process is presented with particular emphasis placed on the NMR aspect of screening.

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