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Review
. 2005 Jun;26(6):283-6.
doi: 10.1016/j.tips.2005.04.007.

Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion

Carmen Aragón  1 , Beatriz López-Corcuera
Affiliations
Review

Glycine transporters: crucial roles of pharmacological interest revealed by gene deletion

Carmen Aragón et al. Trends Pharmacol Sci. 2005 Jun.

Abstract

The functions of the high-affinity glycine transporters (GLYTs) in vivo have been revealed recently using gene-deletion studies. Results from studies of homozygous knockout mice have reinforced the idea that GLYTs might be specific clinical targets to modulate inhibitory glycine-mediated neurotransmission. In addition, molecular and behavioural analysis of heterozygous mice has confirmed the therapeutic potential of GLYT1 inhibitors in the treatment of several neurological and psychiatric disorders.

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