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. 1992 Apr;45(4):458-64.
doi: 10.7164/antibiotics.45.458.

AB3217-A, a novel anti-mite substance produced by a strain of Streptomyces platensis

K Kanbe  1 , Y Mimura, T Tamamura, S Yatagai, Y Sato, A Takahashi, K Sato, H Naganawa, H Nakamura, T Takeuchi, et al.
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Free article

AB3217-A, a novel anti-mite substance produced by a strain of Streptomyces platensis

K Kanbe et al. J Antibiot (Tokyo). 1992 Apr.
Free article

Erratum in

  • J Antibiot (Tokyo) 1992 Jun;45(6):C-2

Abstract

AB3217-A, a novel anti-mite substance, was isolated from the fermentation broth of a streptomycete strain. The strain was isolated from a soil collected at Kita-azumi, Nagano Prefecture, Japan, and identified as Streptomyces platensis AB3217. AB3217-A was purified by Amberlite IR120B, Diaion HP-20 and CM-Sephadex C-25 column chromatographies. The molecular formula was determined as C17H23NO7 by elemental analysis, MS and 13C NMR spectroscopy. The structure of AB3217-A was determined to be (1R,3S,4S,7R,8R,11R,12S,13R)-4,12,13-trihydroxy-8-(4-methoxy phenyl)-6-aza-2,9,14-trioxatricyclo-[9.2.1.0(3,7)]tetradecane by spectroscopic analysis and X-ray crystallographic analysis. The molecule of AB3217-A has unique structure that deacetylanisomycin and beta-D-xylofuranose linked through glycosidic bond and ether bond resulting in the formation of nine-membered ring. AB3217-A showed marked activity against the two spotted spider mite, Tetranychus urticae.

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