doi: 10.1021/ja0522130.
Enantioselective syn-selective scandium-catalyzed ene reactions
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- PMID: 15926812
- DOI: 10.1021/ja0522130
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Enantioselective syn-selective scandium-catalyzed ene reactions
J Am Chem Soc.
.
Abstract
An enantio- and diastereoselective carbonyl-ene reaction catalyzed by chiral scandium pyridyl bis(oxazoline) (pybox) complexes has been developed. Uniformly high enantiomeric excesses and good yields were observed. Use of trisubstituted olefins generated the syn product in high enantio- and diastereoselectivity.
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