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. 2005 Jul;99(7):1526-31.
doi: 10.1016/j.jinorgbio.2005.04.012.

Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: synthesis, structure, spectroscopy, and biological activity

Zahra Afrasiabi  1 , Ekk Sinn, Weisheng Lin, Yinfa Ma, Charles Campana, Subhash Padhye
Affiliations

Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: synthesis, structure, spectroscopy, and biological activity

Zahra Afrasiabi et al. J Inorg Biochem. 2005 Jul.

Abstract

Ni(II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were synthesized and spectroscopically characterized. The X-ray crystal structure of both the complexes describe a distorted octahedral coordination with two tridentate mono-deprotonated ligands. In vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue.

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