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Review
. 2005 Jun 6;169(5):707-10.
doi: 10.1083/jcb.200503053. Epub 2005 May 31.

Cilia and the cell cycle?

Lynne M Quarmby  1 , Jeremy D K Parker
Affiliations
Review

Cilia and the cell cycle?

Lynne M Quarmby et al. J Cell Biol. .

Abstract

A recent convergence of data indicating a relationship between cilia and proliferative diseases, such as polycystic kidney disease, has revived the long-standing enigma of the reciprocal regulatory relationship between cilia and the cell cycle. Multiple signaling pathways are localized to cilia in mammalian cells, and some proteins have been shown to act both in the cilium and in cell cycle regulation. Work from the unicellular alga Chlamydomonas is providing novel insights as to how cilia and the cell cycle are coordinately regulated.

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Figures

Figure 1.
Figure 1.
Fa2p and Cnk2p, cell cycle kinases which localize to distinct regions of cilia. (A) Fa2p-HA localizes to the SOFA region of the proximal axoneme (arrowheads) and also associates with basal bodies. The inset shows a magnified view of Fa2p-HA staining. Image by Moe Mahjoub. (B) Cnk2p-HA localizes along the axoneme in a punctate pattern. Image by Brian Bradley. Indirect immunofluorescence images visualized by anti-HA (red), anti–α-tubulin (blue), and anti-centrin (green).
See this image and copyright information in PMC

References

    1. Badano, J.L., T.M. Teslovich, and N. Katsanis. 2005. The centrosome in human genetic disease. Nat. Rev. Genet. 6:194–205. - PubMed
    1. Bhunia, A.K., K. Piontek, A. Boletta, L. Liu, F. Qian, P.N. Xu, F.J. Germino, and G.G. Germino. 2002. PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell. 109:157–168. - PubMed
    1. Boletta, A., and G.G. Germino. 2003. Role of polycystins in renal tubulogenesis. Trends Cell Biol. 13:484–492. - PubMed
    1. Bradley, B.A., and L. Quarmby. 2005. A NIMA-related kinase, Cnk2p, regulates both flagellar length and cell size in Chlamydomonas J. Cell Sci. 118: In press. - PubMed
    1. Bradley, B.A., J.J. Wagner, and L.M. Quarmby. 2004. Identification and sequence analysis of six new members of the NIMA-related kinase family in Chlamydomonas. J. Eukaryot. Microbiol. 51:66–72. - PubMed

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