Review
doi: 10.1038/nrm1664.
CLIPs and CLASPs and cellular dynamics
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- PMID: 15928712
- DOI: 10.1038/nrm1664
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Review
CLIPs and CLASPs and cellular dynamics
Nat Rev Mol Cell Biol.
2005 Jun.
Abstract
The dynamic properties of microtubules are regulated by plus-end tracking proteins (+TIPs), which associate with the distal ends of microtubules. Among the +TIPs are cytoplasmic linker proteins (CLIPs), which promote microtubule growth and regulate dynein-dynactin localization, and CLIP-associating proteins (CLASPs), which stabilize specific subsets of microtubules on reception of signalling cues. CLIPs and CLASPs interact and cooperate to direct the microtubule network, thereby regulating cellular asymmetry.
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