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Review
. 2005 Jun 1;65(11):4467-70.
doi: 10.1158/0008-5472.CAN-05-0559.

Human T-cell leukemia virus type I at age 25: a progress report

Masao Matsuoka  1 , Kuan-Teh Jeang
Affiliations
Review

Human T-cell leukemia virus type I at age 25: a progress report

Masao Matsuoka et al. Cancer Res. .

Abstract

It has been 25 years since the discovery of human T-cell leukemia virus type I (HTLV-I) and its role in adult T-cell leukemia. Here, in brief, we review the current state of our understanding of HTLV-I epidemiology, viral biology, pathogenesis, and treatment. We discuss how HTLV-I may transform cells through destabilization of cellular genomic integrity and induction of cellular tolerance for chromosomal errors.

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